Porphyrin Accumulation in Skin Tumours and Psoriasis
Author Information
Author(s): Fritsch C, Lehmann P, Stahl W, Schulte K W, Blohm E, Lang K, Sies H, Ruzicka T
Primary Institution: Heinrich-Heine-University Düsseldorf
Hypothesis
The study investigates the time course of porphyrin metabolite formation after topical application of δ-aminolaevulinic acid.
Conclusion
The study suggests that the best time to irradiate superficial epithelial skin tumours is 2 hours after applying δ-aminolaevulinic acid, while for psoriatic lesions, 6 hours is more suitable.
Supporting Evidence
- Porphyrin biosynthesis was investigated in human skin tumours, psoriatic lesions, and normal skin.
- Maximum porphyrin levels in tumours were observed between 2 and 6 hours after treatment.
- Protoporphyrin was the predominant metabolite found in the study.
Takeaway
When treating skin problems with a special cream, the best time to use a light to help is different for skin tumours and psoriasis.
Methodology
Skin areas were treated with δ-aminolaevulinic acid, and levels of total porphyrins, porphyrin metabolites, and proteins were measured in samples excised at various time points.
Digital Object Identifier (DOI)
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