Strong Negative Self Regulation of Prokaryotic Transcription Factors Increases Protein Expression Noise
Author Information
Author(s): Stekel Dov J, Jenkins Dafyd J
Primary Institution: Centre for Systems Biology, School of Biosciences, University of Birmingham
Hypothesis
What is the role of negative self regulation of transcription in regulating the variability of protein abundance?
Conclusion
Strong negative self regulation of transcription may not always control protein abundance but could be favored evolutionarily to limit mRNA usage.
Supporting Evidence
- Strong negative feedback increases variability in protein expression.
- Negative feedback may not effectively control noise in protein expression.
- Negative self regulation can lead to reduced mRNA usage.
Takeaway
When bacteria control their own protein production, it can sometimes make the amount of protein they produce more unpredictable. This might help them save energy by using less mRNA.
Methodology
The study used stochastic modeling techniques and in silico evolution to analyze the effects of negative self regulation on protein expression variability.
Limitations
The models do not account for DNA and cell replication processes, which may influence protein expression variability.
Digital Object Identifier (DOI)
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