A Cluster-Randomised Trial to Compare Home-Based with Health Facility-Based Antiretroviral Treatment in Uganda: Study Design and Baseline Findings
2007

Home-Based vs. Facility-Based HIV Treatment in Uganda

Sample size: 1453 publication Evidence: moderate

Author Information

Author(s): Barbara Amuron, Alex Coutinho, Heiner Grosskurth, Christine Nabiryo, Josephine Birungi, Geoffrey Namara, Jonathan Levin, Peter G. Smith, Shabbar Jaffar

Primary Institution: MRC/UVRI Uganda Research Unit on AIDS

Hypothesis

The effectiveness of home-based care will be approximately equivalent to that of the facility-based care.

Conclusion

The study found that significantly more women than men accessed ART, and both genders presented for treatment at an advanced HIV stage.

Supporting Evidence

  • Women were significantly more likely to access ART than men.
  • Both men and women presented for treatment at an advanced HIV stage.
  • The study was conducted in real-life health service conditions.

Takeaway

This study looked at how people get HIV treatment at home versus at a clinic in Uganda, finding that more women than men are getting treatment.

Methodology

The trial was a cluster-randomised study comparing home-based and facility-based ART delivery in Uganda.

Potential Biases

Participants in the home-based arm may withdraw more due to stigma compared to the facility-based arm.

Limitations

Potential biases due to stigma and participant withdrawal from the home-based arm.

Participant Demographics

The median age of participants was 37 years, with 74% being women.

Statistical Information

P-Value

p=0.9

Statistical Significance

p<0.0001

Digital Object Identifier (DOI)

10.2174/1874613600701010021

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