GRIP: A Tool for Creating Protein Interaction Datasets
Author Information
Author(s): Fiona Browne, Haiying Wang, Huiru Zheng, Francisco Azuaje
Primary Institution: University of Ulster at Jordanstown, Northern Ireland, UK
Hypothesis
Can a web-based system simplify the construction of Gold Standard datasets for protein-protein interaction prediction?
Conclusion
GRIP simplifies and speeds up the process of constructing reference datasets for protein-protein interactions.
Supporting Evidence
- GRIP allows users to create both positive and negative reference datasets for protein interactions.
- The tool integrates functionalities for verifying protein complex membership and searching for protein complex information.
- GRIP is designed to be user-friendly and accessible via a web browser.
Takeaway
GRIP is a tool that helps scientists quickly create lists of proteins that interact with each other, making research easier and faster.
Methodology
GRIP allows users to generate reference datasets for protein interactions by extracting data from established databases and provides functionalities for verifying protein complex membership.
Potential Biases
Potential bias in selecting protein complexes if not randomized properly.
Limitations
The initial upper limit of 10,000 cases may restrict users needing larger datasets.
Digital Object Identifier (DOI)
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