Higher muscle mass linked to better kidney function in healthy people
Author Information
Author(s): Westenberg Lisa B, van Londen Marco, Zorgdrager Marcel, de Borst Martin H, Viddeleer Alain R, Bakker Stephan J L, Pol Robert A
Primary Institution: University Medical Center Groningen, University of Groningen
Hypothesis
Higher muscle mass, quality, and 24-h CER levels are associated with higher mGFR.
Conclusion
The study found a significant association between higher skeletal muscle mass and higher kidney function in healthy individuals.
Supporting Evidence
- Higher skeletal muscle area was positively correlated with 24-h urinary creatinine excretion rate.
- Multivariable analyses showed that higher muscle mass was associated with higher mGFR.
- Female sex and age were also significant determinants of mGFR.
Takeaway
If you have more muscle, your kidneys might work better. This study looked at healthy people and found that muscle helps kidneys do their job.
Methodology
This cross-sectional study used CT scans to measure skeletal muscle area and density, and assessed kidney function through mGFR measurements.
Potential Biases
The use of contrast in CT scans may have influenced muscle density measurements.
Limitations
The cross-sectional design limits causal inferences, and the study primarily included individuals of European descent, affecting generalizability.
Participant Demographics
The study included 888 healthy participants, with an average age of 53 years and 49% male.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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