(S,Z)-1-Chloro-3-[(3,4,5-trimethoxybenzylidene)amino]propan-2-ol
2011
Study of a Key Intermediate for Linezolid Synthesis
publication
Evidence: moderate
Author Information
Author(s): Ren Yun, Qian Shan, Hai Li, Fan Wei, Wu Yong
Primary Institution: West China School of Pharmacy, Sichuan University
Hypothesis
The study aims to develop an efficient methodology for synthesizing S,Z-1-chloro-3-(3,4,5-trimethoxybenzylideneamino)propan-2-ol.
Conclusion
The crystal structure of the title compound was successfully determined, revealing specific geometric arrangements of methoxy groups.
Supporting Evidence
- The title compound is a key intermediate for synthesizing Linezolid, which treats serious multi-drug resistant bacterial infections.
- The crystal structure shows that two methoxy groups are nearly coplanar with the benzene ring.
Takeaway
The researchers created a compound that helps make a medicine called Linezolid, which fights tough bacterial infections.
Methodology
The compound was synthesized from 3,4,5-trimethoxybenzaldehyde and S-2-(chloromethyl)oxirane in methyl tert-butyl ether.
Digital Object Identifier (DOI)
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