Red Cell Distribution Width and 30-Day Mortality in Sepsis-Associated Liver Injury
Author Information
Author(s): Ao Ting, Huang Yingxiu, Zhen Peng, Hu Ming
Primary Institution: Beijing Luhe Hospital, Capital Medical University, Beijing, China
Hypothesis
This study aimed to evaluate the association between RDW and 30-day mortality in SALI patients.
Conclusion
Elevated RDW is independently associated with higher 30-day mortality in patients with SALI.
Supporting Evidence
- 46.1% of patients had RDW > 15.5%.
- The 30-day mortality rate was 35.5%.
- RDW was significantly higher in non-survivors compared to survivors.
- Cox regression identified RDW as an independent risk factor for 30-day mortality.
- Subgroup analyses demonstrated consistent findings across various groups.
Takeaway
If you have a high red cell distribution width (RDW), it might mean you're more likely to get very sick and not survive if you have liver problems caused by sepsis.
Methodology
A retrospective cohort study using data from the MIMIC-IV database, focusing on patients with SALI admitted to the ICU.
Potential Biases
Potential for selection bias due to the retrospective nature of the study.
Limitations
The study is retrospective and may be subject to selection bias and unidentified confounders.
Participant Demographics
Mean age 68.7 years, 61.8% male.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 1.09 to 1.19
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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