Comparative Study on Pain Relief from Propofol Injection
Author Information
Author(s): Singh Dhananjay Kumar, Jindal Parul, Singh Gaurav
Primary Institution: Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun, India
Hypothesis
The study aims to assess the efficacy of pretreatment with various drugs to alleviate the pain caused by propofol injection.
Conclusion
Granisetron was the most effective drug in reducing pain from propofol injection, followed by nitroglycerine and magnesium sulfate.
Supporting Evidence
- Granisetron reduced pain incidence to 24% at 5 seconds compared to 80% in the control group.
- Magnesium sulfate reduced pain incidence to 56% at 5 seconds compared to the control group.
- Nitroglycerine reduced pain incidence to 48% at 5 seconds compared to the control group.
Takeaway
Doctors tested different medicines to see which one helps reduce the pain when giving a medicine called propofol. Granisetron worked the best.
Methodology
100 ASA I and II adults were randomly divided into four groups to receive different pretreatments before propofol injection, and pain was assessed using a verbal response scale.
Potential Biases
The observer was blinded to the treatment groups, reducing potential bias in pain assessment.
Limitations
The study excluded patients outside the age range of 21-50 years and those with certain medical conditions, which may limit generalizability.
Participant Demographics
Majority of participants were males (59%) and belonged to ASA Grade I (81%).
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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