Combining a Ketogenic Diet with 2-Deoxy-D-Glucose to Treat Brain Tumors in Mice
Author Information
Author(s): Jeremy Marsh, Purna Mukherjee, Thomas N. Seyfried
Primary Institution: Boston College
Hypothesis
Can low doses of 2-deoxy-D-glucose (2-DG) act synergistically with a restricted ketogenic diet to manage malignant astrocytoma growth in mice?
Conclusion
The combination of a restricted ketogenic diet and low doses of 2-DG significantly reduced tumor growth more than either treatment alone.
Supporting Evidence
- Tumor weights were about 48% and 80% lower in the KD-R and KD-R+2-DG groups, respectively, than in the SD-UR group.
- Mouse health and vitality was better in the KD-R group than in the KD-R+2-DG group.
- The study suggests that combining drugs that inhibit glycolysis with restricted ketogenic diets could enhance inhibition of malignant astrocytoma growth.
Takeaway
This study found that a special diet and a small amount of a drug worked better together to help mice with brain tumors than either one alone.
Methodology
Adult C57BL/6J mice with CT-2A malignant astrocytoma were fed either a standard diet or a restricted ketogenic diet with or without 2-DG for 10 days.
Potential Biases
Potential bias due to the lack of blinding in treatment assignment.
Limitations
The study did not include an unrestricted ketogenic diet group for comparison.
Participant Demographics
Adult male C57BL/6J mice, approximately 14 weeks old.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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