Ellagic Acid from Phyllanthus urinaria Reduces Angiogenesis
Author Information
Author(s): Huang Sheng-Teng, Wang Chen-Yu, Yang Rong-Chi, Wu Hsiao-Ting, Yang Su-Hui, Cheng Yung-Chi, Pang Jong-Hwei S.
Primary Institution: Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan
Hypothesis
This study aimed to assess the potential anti-angiogenic mechanism of Phyllanthus urinaria and identify the major compound responsible for this effect.
Conclusion
Ellagic Acid is the active compound in Phyllanthus urinaria that exhibits anti-angiogenic activity and inhibits the secretion of MMP-2 protein from human vascular endothelial cells.
Supporting Evidence
- P. urinaria extract inhibited angiogenesis in chicken embryos.
- Ellagic Acid reduced MMP-2 activity in a dose-dependent manner.
- Both P. urinaria and Ellagic Acid showed similar effects on MMP-2 activity in human vascular endothelial cells.
Takeaway
Phyllanthus urinaria, a plant, has a special ingredient called Ellagic Acid that helps stop the growth of new blood vessels, which is important in cancer.
Methodology
The study used chorioallantoic membrane assays and human vascular endothelial cells to evaluate the anti-angiogenic effects and MMP-2 activity.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website