The induction of bladder cancer in portally diverted rats
1992
Bladder Cancer Induction in Rats with Portal Diversion
Sample size: 136
publication
Evidence: moderate
Author Information
Author(s): V. Jaffe, B. Alexander, A.B. Price, G.D. Zanelli
Primary Institution: Hammersmith Hospital
Hypothesis
Does portal diversion lead to the induction of bladder cancer in rats?
Conclusion
The study found a significant incidence of bladder stones and tumors in rats subjected to portal diversion.
Supporting Evidence
- 39 out of 136 rats developed bladder stones after portal diversion.
- 17 out of 136 rats developed bladder tumors after portal diversion.
- In over 200 control animals, there were no cases of bladder stones or tumors.
Takeaway
When rats had their blood flow changed to bypass the liver, many developed bladder stones and tumors.
Methodology
Rats underwent pancreatico-lienal portal diversion, and their bladders were examined post-mortem for stones and tumors.
Limitations
The study does not establish a direct correlation between the presence of stones and tumor induction.
Participant Demographics
Rats were used in the study, with a focus on those subjected to portal diversion.
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