RAAS Gene Polymorphisms and Chronic Kidney Disease in Type 2 Diabetes
Author Information
Author(s): Prasad Pushplata, Tiwari Arun K, Kumar KM Prasanna, Ammini AC, Gupta Arvind, Gupta Rajeev, Sharma AK, Rao AR, Nagendra R, Chandra T Satish, Tiwari SC, Rastogi Priyanka, Gupta B Lal, Thelma BK
Primary Institution: Department of Genetics, University of Delhi South Campus, New Delhi, India
Hypothesis
The study investigates the contribution of selected RAAS gene polymorphisms to chronic renal insufficiency among type 2 diabetic Asian Indian subjects.
Conclusion
SNPs in the angiotensinogen, aldosterone synthase, and chymase genes are significantly associated with diabetic chronic renal insufficiency in Indian patients.
Supporting Evidence
- Met235Thr SNP in angiotensinogen gene showed a significant association with chronic renal insufficiency.
- T>C (-344) SNP in aldosterone synthase gene was significantly associated with diabetic renal disease.
- G>A (-1903) SNP in chymase gene was found to be associated with chronic renal insufficiency.
- Logistic regression analysis confirmed the association of Met235Thr SNP with chronic renal insufficiency.
Takeaway
The study found that certain genes can help predict kidney problems in people with diabetes, especially in Indian patients.
Methodology
The study used a case-control approach to genotype twelve SNPs from six genes related to the RAAS pathway in diabetic patients with and without chronic renal insufficiency.
Potential Biases
Potential bias due to lack of treatment details and the small sample size may affect the generalizability of the findings.
Limitations
The study had a small sample size and relied on multiple criteria for diagnosing diabetic renal disease.
Participant Demographics
Participants included 196 subjects with chronic renal insufficiency and 225 controls without renal disease, primarily Asian Indians.
Statistical Information
P-Value
p<0.01
Confidence Interval
95%CI: 1.88–4.59 for Thr/Thr genotype
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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