Expression of MUC1 mucins inversely correlated with post-surgical survival of renal cell carcinoma patients
1999
MUC1 Mucins and Renal Cell Carcinoma Survival
publication
Evidence: moderate
Author Information
Author(s): Fujita K, Denda K, Yamamoto M, Matsumoto T, Fujime M, Irimura T
Primary Institution: Juntendo University School of Medicine
Hypothesis
The expression of MUC1 mucins is inversely correlated with post-surgical survival of renal cell carcinoma patients.
Conclusion
Higher levels of sialylated MUC1 mucins in renal cell carcinoma patients are associated with worse survival outcomes.
Supporting Evidence
- MUC1 mucins were found in higher levels in advanced stages of renal cell carcinoma.
- The expression of sialylated MUC1 mucins was localized to specific kidney cell types.
- Patients with higher MUC1 expression had shorter disease-free survival periods.
Takeaway
If patients with kidney cancer have more of a certain protein called MUC1, they might not live as long after surgery.
Methodology
Immunohistochemical studies and Western blot analysis were used to examine MUC1 mucin expression in renal cell carcinoma tissues.
Digital Object Identifier (DOI)
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