CXCL13 in Breast Cancer
Author Information
Author(s): Panse J, Friedrichs K, Marx A, Hildebrandt Y, Luetkens T, Bartels K, Horn C, Stahl T, Cao Y, Milde-Langosch K, Niendorf A, Kröger N, Wenzel S, Leuwer R, Bokemeyer C, Hegewisch-Becker S, Atanackovic D
Primary Institution: University Medical Center Hamburg-Eppendorf
Hypothesis
Is CXCL13 overexpressed in breast cancer tissues and serum?
Conclusion
CXCL13 is overexpressed in breast cancer tissues, and elevated serum levels are found in patients with metastatic disease.
Supporting Evidence
- CXCL13 was found to be the most strongly overexpressed chemokine in breast cancer tissues.
- Serum concentrations of CXCL13 were significantly higher in patients with metastatic disease compared to controls.
- A strong correlation was observed between CXCL13 and its receptor CXCR5 in breast cancer tissues.
Takeaway
This study found that a protein called CXCL13 is found in higher amounts in breast cancer tissues and blood, especially in patients with advanced cancer.
Methodology
Microarray analyses, real-time PCR, Western blot, ELISA, and immunohistochemistry were used to analyze CXCL13 expression in breast cancer tissues and serum.
Potential Biases
Potential bias in sample selection and the influence of treatment on serum levels of CXCL13.
Limitations
The study may not fully represent all breast cancer types due to the specific patient population and sample collection methods.
Participant Demographics
The study included 136 breast cancer patients with varying stages of the disease.
Statistical Information
P-Value
0.0004
Statistical Significance
p=0.0004
Digital Object Identifier (DOI)
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