Response to Dr. Remvikos' Letter
Author Information
Author(s): P. Mullen, W.R. Miller
Primary Institution: ICRF Medical Oncology Unit, Western General Hospital
Conclusion
The authors defend their original work on DNA analysis from fine needle aspirates, emphasizing the importance of understanding variations in breast cancer samples.
Supporting Evidence
- Variations in DNA analysis can occur due to the heterogeneous nature of breast tumors.
- Sequential fine needle aspirates may yield different results due to variations in tumor cell populations.
- Successful treatment may not always correlate with changes in DNA profiles.
Takeaway
The authors explain that while fine needle aspirates can provide important information about breast cancer, there are many factors that can affect the results, making them tricky to interpret.
Methodology
The study involved using fine needle aspirates for DNA analysis and comparing results with surgically excised biopsies.
Limitations
The study acknowledges the potential pitfalls in interpreting sequential aspirates due to variations in cell populations.
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