DNA Polymerase a Positive Cell Rate in Colorectal Cancer and Its Relationship to Prognosis
Author Information
Author(s): A. Yamaguchi, Y. Hirono, S. Fushida, Y. Kurosaka, M. Kanno, Y. Yonemura, I. Miyazaki
Primary Institution: Department of Surgery II, School of Medicine, Kanazawa University, Japan
Hypothesis
The DNA polymerase a positive cell rate may be a useful prognostic marker of colorectal cancers.
Conclusion
Patients with high growth fraction tumors had significantly poorer prognoses than those with low growth fraction tumors.
Supporting Evidence
- High growth fraction tumors were more frequently associated with liver metastasis.
- Patients with high growth fraction tumors had significantly poorer prognoses than those with low growth fraction tumors.
- DNA polymerase a positive cell rates were found to be independent prognostic factors.
Takeaway
This study found that the more active the cancer cells are, the worse the patients' outcomes tend to be.
Methodology
The study used immunohistochemical techniques to analyze DNA polymerase a positive cell rates in biopsy and resected specimens from colorectal cancer patients.
Limitations
The study only included patients from a single institution and may not be generalizable.
Participant Demographics
The study included 63 patients with primary colorectal cancers, comprising 36 lesions of colon and 27 lesions of rectal cancers.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
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