Studying Heart Changes After a Heart Attack Using MRI
Author Information
Author(s): Heydari Bobby, Abdullah Shuaib M, Coelho-Filho Otavio, Mongeon François-Pierre, Alanna Harris, Chung Yiu Cho, van der Geest Rob J, Jerosch-Herold Michael, Antman Elliott, Kwong Raymond Y
Primary Institution: Brigham and Women's Hospital, Boston, MA, USA
Hypothesis
A dynamic increase of the proportion of infarct core relative to peri-infarct zone (PIZ) following acute myocardial infarction (MI) may be associated with adverse remodeling.
Conclusion
An increase of the infarct core to PIZ ratio during the first 6 months of infarct healing was associated with adverse left ventricular remodeling.
Supporting Evidence
- Total infarct size decreased from 17±14g to 13±12g over 6 months.
- Infarct core size decreased from 5.5±5.6g to 4.0±4.0g over 6 months.
- PIZ size decreased from 11.5±9g to 9±8g over 6 months.
- LVEF improved from 55±10% to 58±8% over 6 months.
- Dynamic change of the infarct core to PIZ ratio correlated with changes in LVESV and LVEF.
Takeaway
This study looked at how heart tissue changes after a heart attack, finding that certain changes can mean the heart might not heal well.
Methodology
The study prospectively analyzed 63 patients with acute myocardial infarction using cardiac magnetic resonance imaging (CMR) 2-4 weeks post-MI and followed up at 6 months.
Participant Demographics
Mean age was 59 ± 12 years, and 70% were male.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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