Breastfeeding and Chronic Hepatitis B: A Meta-Analysis
Author Information
Author(s): Zheng Yingjie, Lu Yihan, Ye Qi, Xia Yugang, Zhou Yueqin, Yao Qingqing, Wei Shan
Primary Institution: Fudan University
Hypothesis
Does breastfeeding by chronic hepatitis B mothers increase the risk of CHB infection in vaccinated infants?
Conclusion
Breastfeeding by mothers with chronic hepatitis B does not significantly increase the risk of CHB infection in vaccinated infants.
Supporting Evidence
- 4.32% of infants born to CHB mothers develop CHB infection.
- The risk difference for breastfeeding versus formula feeding was -0.8%.
- Breastfeeding is not associated with additional risk of CHB infection in vaccinated infants.
- 32 studies were included in the meta-analysis.
- 42.0% of mothers were designated with high infectivity.
Takeaway
Moms with chronic hepatitis B can breastfeed their babies without worrying about spreading the virus, especially if the babies have been vaccinated.
Methodology
A meta-analysis of 32 studies examining the association between breastfeeding and CHB infection risk in infants vaccinated against HBV.
Potential Biases
Differential loss to follow-up and unknown confounders may introduce bias.
Limitations
Potential biases in follow-up studies and variations in studied populations may affect results.
Participant Demographics
Infants born to chronic hepatitis B mothers, with a mix of high and low infectivity markers.
Statistical Information
P-Value
0.789
Confidence Interval
-1.6%, 0.1%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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