ATR activation in response to ionizing radiation: still ATM territory
2006
Understanding ATM and ATR in DNA Damage Response
publication
Evidence: moderate
Author Information
Author(s): Myriam Cuadrado, Barbara Martinez-Pastor, Oscar Fernandez-Capetillo
Primary Institution: Spanish National Cancer Center
Hypothesis
How do ATM and ATR interact in response to DNA damage?
Conclusion
The study reveals that ATM and ATR signaling pathways actively crosstalk in response to ionizing radiation.
Supporting Evidence
- ATM and ATR are both crucial for responding to DNA damage.
- Recent studies show that ATM can activate ATR in response to ionizing radiation.
- Phosphorylation of Chk1 is a key indicator of ATR activity.
Takeaway
When DNA gets damaged, two important proteins, ATM and ATR, work together to fix it, and they help each other do their jobs better.
Methodology
The study discusses the roles of ATM and ATR in signaling pathways activated by DNA double-strand breaks.
Digital Object Identifier (DOI)
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