New Approaches in Cancer Pharmacology: Drug Design and Development
1992
New Approaches in Cancer Pharmacology
publication
Author Information
Author(s): P. Workman, D'Incalci, Broggini, Hartley, Claude Helene, Sikora, Guiterrez, John Hickman, Michael Jarman, Paul Workman, Merrill Egorin, Gilberto Schwartsmann, K.R. Harrap
Conclusion
The monograph discusses the need for more effective cancer drugs and highlights various innovative strategies in drug design and development.
Supporting Evidence
- The contributors are all acknowledged experts in their fields.
- The review discusses the biochemical events underpinning the cytotoxicities of alkylating agents.
- Antisense oligonucleotides can achieve high selectivity in targeting specific cells.
- Gene replacement therapy is suggested as a viable strategy for cancer treatment.
- New anti-oestrogens are being developed to combat tumour resistance.
- Bioreductive drugs are being designed to exploit the hypoxic environment of solid tumours.
- Optimal dosing strategies for anti-cancer drugs are necessary due to their low therapeutic indices.
- The EORTC is addressing current strategies in anti-cancer drug discovery.
Takeaway
This book talks about new ways to create better medicines for cancer by understanding how cancer cells work and finding specific targets to attack.
Limitations
The studies discussed do not account for cellular metabolism.
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