Correlation of Tissue Biopsy and Fine Needle Aspiration Cytology with PET Results
Author Information
Author(s): Daniel Rosen, Bruce Herrington, Peeyush Bhargava, Rodolfo Laucirica, Gordana Verstovsek
Primary Institution: Baylor College of Medicine
Hypothesis
The study aims to evaluate the overall accuracy of positive PET scans at detecting malignant lesions.
Conclusion
An SUV cutoff value of 2.5 does not always adequately discriminate between malignant and benign processes.
Supporting Evidence
- 46 lesions were interpreted as positive on PET scan, of which 80% were malignant.
- 24 cases diagnosed as negative by PET impression were all benign.
- The overall sensitivity and specificity for PET impression was 100% and 75%, respectively.
Takeaway
PET scans can show if a tissue is likely cancerous, but sometimes they can be wrong, so doctors need to do more tests to be sure.
Methodology
The study analyzed electronic records of patients who had a PET-positive result followed by a biopsy or fine needle aspiration.
Potential Biases
The study may have bias due to the small number of true negative and false negative cases.
Limitations
The study included patients with known history of cancer, which may not represent the general population.
Participant Demographics
54 patients, predominantly male (53 males, 1 female), average age 66.5 years.
Statistical Information
P-Value
p<0.0017
Statistical Significance
p<0.0017
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website