2,2,5,7,8-Pentamethylchroman-6-yl 2,3,4,6-tetra-O-acetyl-α-d-glucopyranoside from synchrotron data
2011
Structure of a Water-Soluble Glucoside Derived from Vitamin E
publication
Evidence: moderate
Author Information
Author(s): Krzysztof Brzezinski, Piotr Wałejko, Aneta Baj, Stanisław Witkowski, Zbigniew Dauter
Primary Institution: National Cancer Institute, Argonne National Laboratory
Hypothesis
The study investigates the crystal structure of a water-soluble glucoside derived from vitamin E to understand its properties.
Conclusion
The crystal structure of the compound reveals two independent molecules with disordered conformations.
Supporting Evidence
- The crystal structure was solved and refined using synchrotron diffraction data.
- The occupancy of the major conformers was found to be 0.858 and 0.523.
- The study provides insights into the molecular conformation of the glucoside.
Takeaway
The researchers looked at how a special form of vitamin E can be made more water-friendly, which helps it dissolve better.
Methodology
The compound was synthesized using a modified Helferich method and crystallized from ethanol.
Digital Object Identifier (DOI)
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