NIGROSTRIATAL DOPAMINE AND PHYSICAL PERFORMANCE FATIGABILITY IN COMMUNITY-DWELLING OLDER ADULTS
2024
Dopamine and Physical Performance in Older Adults
Sample size: 125
publication
Evidence: moderate
Author Information
Author(s): Rosano Caterina, Gay Emma, Coen Paul, Rosso Andrea, Newman Anne, Kritchevsky Stephen, Glynn Nancy
Primary Institution: University of Pittsburgh
Hypothesis
Higher nigrostriatal dopaminergic integrity would be associated with lower performance fatigability in community-dwelling older adults.
Conclusion
Higher dopamine integrity in the posterior putamen is linked to lower performance fatigability in older adults.
Supporting Evidence
- Higher dopamine integrity in the posterior putamen is significantly associated with lower performance fatigability.
- Results remained significant after adjusting for demographics, cognition, and other factors.
Takeaway
Older people with better dopamine function in a specific brain area can walk longer without getting tired.
Methodology
Performance fatigability was measured during a fast-paced 400 meter walk, and dopamine integrity was assessed using PET imaging.
Participant Demographics
Mean age 75.4 years, 59% women.
Statistical Information
Confidence Interval
95% CI:-2.11, -0.25
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website