Non-invasive cardiac assessment in high risk patients (The GROUND study): rationale, objectives and design of a multi-center randomized controlled clinical trial

2008

Non-invasive Cardiac Assessment in High-Risk Patients: The GROUND Study

Sample size: 1200 publication 10 minutes Evidence: moderate

Author Information

Author(s): Alexander M de Vos, Annemarieke Rutten, Hester J van de Zaag-Loonen, Michiel L Bots, Riksta Dikkers, Robert A Buiskool, Willem P Mali, Daniel D Lubbers, Arend Mosterd, Mathias Prokop, Benno J Rensing, Maarten J Cramer, H Wouter van Es, Frans L Moll, Eric D van de Pavoordt, Pieter A Doevendans, Birgitta K Velthuis, Albert J Mackaay, Felix Zijlstra, Matthijs Oudkerk

Primary Institution: University Medical Center Utrecht

Hypothesis

Does a cardiac imaging algorithm using non-invasive techniques followed by treatment reduce the risk of cardiovascular disease in patients with peripheral arterial disease who are free from cardiac symptoms?

Conclusion

The GROUND study aims to determine if non-invasive cardiac imaging can lower cardiovascular event risks in asymptomatic patients with peripheral arterial disease.

Supporting Evidence

Peripheral arterial disease is linked to a higher risk of cardiovascular events.
Non-invasive imaging techniques can help identify cardiac issues in asymptomatic patients.
Patients with peripheral arterial disease often have undiagnosed coronary artery disease.

Takeaway

This study is trying to find out if using special heart scans can help people with leg artery problems live longer and healthier lives.

Methodology

A multi-center, randomized controlled trial comparing a cardiac imaging algorithm with standard care in patients with peripheral arterial disease.

Potential Biases

Potential biases may arise from patient selection and the randomization process.

Limitations

The study may not account for all variables affecting cardiovascular outcomes, and results may not be generalizable to all populations.

Participant Demographics

Patients aged 50 years or older with peripheral arterial disease, without symptomatic cardiac disease.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1745-6215-9-49

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