Lipid Nanoparticle Formulations for Skin Delivery of Cannabidiol
Author Information
Author(s): Calienni Maria Natalia, Scavone Mirian Ana, Sanguinetti Ana Paula, Corleto Merlina, Di Meglio Magalí Rocío, Raies Pablo, Cristos Diego Sebastián, Maffia Paulo César, Montanari Jorge
Primary Institution: Universidad Nacional de Hurlingham (UNAHUR)
Hypothesis
Can lipid nanoparticles effectively deliver cannabidiol to deeper layers of the skin while maintaining its stability and antibacterial properties?
Conclusion
The developed cannabidiol nanoformulations show potential for treating skin diseases by enhancing delivery and exhibiting antibacterial effects.
Supporting Evidence
- Three nanoformulations exhibited the best size and reproducibility values.
- The formulations were stable and protected the active ingredient.
- They succeeded in delivering cannabidiol to deep skin layers.
- The formulations demonstrated antibacterial activity against Staphylococcus aureus.
- Encapsulation increased the stability of cannabidiol over time.
- Skin penetration assays showed improved delivery of cannabidiol compared to free cannabidiol.
- All three CBD-loaded nanoparticles exhibited the same minimal inhibitory concentration against bacteria.
Takeaway
This study created tiny particles to help deliver a natural compound called cannabidiol into the skin better, which could help with skin problems.
Methodology
Solid lipid nanoparticles and nanostructured lipid carriers were prepared and characterized for their properties, stability, and skin penetration using human skin samples.
Limitations
The study primarily used in vitro models and human skin samples from a single donor, which may limit the generalizability of the findings.
Participant Demographics
Human skin samples were obtained from a healthy 45-year-old Caucasian woman.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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