Non-steroidal anti-inflammatory drugs and bladder cancer prevention
Author Information
Author(s): Castelao J E, Yuan J-M, Gago-Dominguez M, Yu M C, Ross R K
Primary Institution: USC/Norris Comprehensive Cancer Center
Hypothesis
Is there a relationship between the use of analgesics and the risk of bladder cancer?
Conclusion
Regular use of analgesics was not associated with an increased risk of bladder cancer, and some types may even offer protective effects.
Supporting Evidence
- Regular analgesic users were at a decreased risk of bladder cancer overall.
- Intake of phenacetin was positively related to bladder cancer risk in a dose-dependent manner.
- Intake of all classes of NSAIDs, except pyrazolon derivatives, were negatively associated with bladder cancer risk.
- Acetic acids seemed to exhibit the strongest protective effect.
Takeaway
This study looked at whether taking pain relievers like aspirin and acetaminophen affects the chances of getting bladder cancer. It found that using these medicines regularly doesn't increase the risk and might even help protect against it.
Methodology
A population-based case–control study with 1514 bladder cancer cases and matched controls, collecting detailed medication use and medical history through interviews.
Participant Demographics
Participants included men and women matched by sex, date of birth, and race.
Statistical Information
Confidence Interval
95% CI = 0.68–0.96
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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