Measuring Heart Oxygen Use with 17O-CMR
Author Information
Author(s): Zheng Jie, Muccigrosso David, Abendschein Dana
Primary Institution: Washington University In St. Louis, Saint Louis, MO, USA
Hypothesis
This study aims to develop a new non-invasive CMR method using 17O based blood tracer to assess myocardial oxygenation and MVO2.
Conclusion
The 17O-CMR may provide a direct and non-invasive measurement of oxygen consumption for better evaluations of patients with various heart conditions.
Supporting Evidence
- The averaged MVO2 in normal dogs was 3.96 ± 0.97 μmol/g/min, consistent with PET measurements.
- For the 70% stenotic dog, MVO2 was 2.84 μmol/g/min in the normal segment and 1.57 μmol/g/min in the lateral region.
- The study showed that the oxygen deficit area was smaller than the hypo-perfusion size.
Takeaway
This study is like finding a new way to see how much oxygen the heart is using without needing to do anything invasive.
Methodology
The study involved injecting a 17O blood tracer into normal and ischemic dogs and using CMR imaging to measure myocardial oxygen consumption.
Participant Demographics
Normal mongrel dogs and myocardial ischemic dogs.
Digital Object Identifier (DOI)
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