Ki-67 and S-phase as Prognostic Tools in Soft-Tissue Sarcoma
Author Information
Author(s): Huuhtanen R L, Blomqvist C P, Wiklund T A, Böhling T O, Virolainen M J, Tukiainen E J, Tribukait B, Andersson L C
Primary Institution: Helsinki University Central Hospital
Hypothesis
Is Ki-67 a better prognostic variable than S-phase fraction in soft-tissue sarcoma?
Conclusion
Ki-67 is a useful prognostic tool for soft-tissue sarcoma patients, while S-phase fraction is less reliable at higher cut-point values.
Supporting Evidence
- Ki-67 score correlated strongly with ploidy, S-phase fraction, and grade.
- Ki-67 was a stronger predictor of metastasis-free survival and disease-specific overall survival than S-phase fraction.
- S-phase fraction lost its prognostic power at higher cut-point values.
Takeaway
Doctors can use a test called Ki-67 to help predict how well patients with soft-tissue sarcoma will do, and it works better than another test called S-phase.
Methodology
Ki-67 scores were evaluated immunohistochemically and S-phase fractions were determined using flow cytometry from primary tumors.
Participant Demographics
All patients had either limb or superficial trunk tumors.
Statistical Information
P-Value
0.003 and 0.04
Statistical Significance
p=0.003 and p=0.04
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website