1-Benzyl-1H-benzimidazol-2(3H)-one
2011
Synthesis of a New Benzimidazol-2-One Derivative
publication
Author Information
Author(s): Ouzidan Younes, Essassi El Mokhtar, Luis Santiago V., Bolte Michael, El Ammari Lahcen
Primary Institution: Université Sidi Mohamed, Ben Abdallah
Hypothesis
The study aims to synthesize a new benzimidazol-2-one derivative using benzyl chloride and 1H-benzimidazol-2-one.
Conclusion
The synthesized compound features a planar structure with specific dihedral angles and forms inversion dimers through hydrogen bonding.
Supporting Evidence
- The compound was synthesized under mild conditions.
- The maximum deviation from the mean plane of the rings is very small.
- The dihedral angle between the benzimidazole and phenyl ring is specified.
Takeaway
The researchers made a new chemical compound that could be useful in medicine by combining two specific chemicals together.
Methodology
The synthesis involved reacting 1H-benzimidazol-2-one with benzyl chloride in the presence of potassium carbonate and tetra-n-butylammonium bromide.
Digital Object Identifier (DOI)
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