Effects of Vitamin C and Other Antioxidants on Tumor Cells
Author Information
Author(s): Casciari J J, Riordan N H, Schmidt T L, Meng X L, Jackson J A, Riordan H D
Primary Institution: Bio-Communications Research Institute, Center for the Improvement of Human Functioning International
Hypothesis
Can ascorbate, in combination with other antioxidants, kill tumor cells in a hollow fibre in vitro model at clinically achievable concentrations?
Conclusion
Ascorbate, especially when combined with lipoic acid, can effectively kill tumor cells in vitro at concentrations that may be achievable in humans.
Supporting Evidence
- Ascorbate increased the percentage of apoptotic cells in SW620 hollow fibre tumours.
- Lipoic acid reduced the LC50 of ascorbate in hollow fibre tumours significantly.
- Ascorbate levels in human blood plasma can reach tumoricidal concentrations after intravenous infusions.
Takeaway
Vitamin C can help kill cancer cells, especially when mixed with other vitamins, and doctors might be able to use it safely in treatments.
Methodology
The study assessed the anti-cancer efficacy of ascorbate and other antioxidants using annexin V staining and survival assays in a hollow fibre tumor model.
Digital Object Identifier (DOI)
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