Expression of Adhesion G Protein-Coupled Receptors in Mice and Rats
Author Information
Author(s): Haitina Tatjana, Olsson Fredrik, Stephansson Olga, Alsiö Johan, Roman Erika, Ebendal Ted, Schiöth Helgi B, Fredriksson Robert
Primary Institution: Uppsala University
Hypothesis
The study aims to analyze the expression profiles of the entire family of Adhesion G protein-coupled receptors (GPCRs) in mouse and rat.
Conclusion
The study found that many Adhesion GPCRs are expressed in the CNS and have unique expression profiles.
Supporting Evidence
- The study produced comparable expression profiles for each member of the Adhesion GPCR family.
- The majority of Adhesion GPCRs are expressed in the CNS or ubiquitously.
- Related Adhesion GPCRs have considerable overlap in their expression profiles.
Takeaway
This study looked at how different receptors in the brain and body work and found that many of them are important for brain functions.
Methodology
The study used quantitative real-time PCR to analyze the expression of 30 Adhesion GPCR family members in various tissues.
Limitations
The majority of Adhesion GPCRs are poorly studied, and the expression data is limited to a few tissues.
Digital Object Identifier (DOI)
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