Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts
2008
The role of endothelial-to-mesenchymal transition in cancer progression
publication
Evidence: moderate
Author Information
Author(s): Potenta S, Zeisberg E, Kalluri R
Primary Institution: Beth Israel Deaconess Medical Center and Harvard Medical School
Hypothesis
EndMT may play a significant role in cancer progression.
Conclusion
EndMT is an important source of cancer-associated fibroblasts that facilitate tumor progression.
Supporting Evidence
- EndMT accounts for up to 40% of cancer-associated fibroblasts.
- CAFs play an important role in tumor progression.
- EndMT-derived cells may have a unique role in tumor progression.
Takeaway
Some cells in tumors can change from one type to another, which helps the tumor grow. This change is called EndMT.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website