SLC2A9 Gene Variation and Type 2 Diabetes in Han Chinese
Author Information
Author(s): Liu Wan-Chun, Hung Chi-Chih, Chen Szu-Chia, Lin Ming-Yen, Chen Ling-I, Hwang Daw-Yang, Chang Jer-Ming, Tsai Jer-Chia, Chen Hung-Chun, Hwang Shang-Jyh
Primary Institution: Kaohsiung Medical University
Hypothesis
The SLC2A9 gene variations are associated with type 2 diabetes mellitus in Han Chinese.
Conclusion
The SNP rs1014290 within the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese.
Supporting Evidence
- The SNP rs1014290 is associated with a 0.12-fold decreased risk of type 2 diabetes.
- Each copy of the minor C-allele results in a decrease in serum glucose and uric acid levels.
- The effect of SNP rs1014290 on glucose and uric acid levels is more pronounced in females.
- Lower glucose and uric acid levels were found to be associated with the rs1014290 SNP.
- The association between type 2 diabetes and SLC2A9 variation is independent of uric acid effects.
Takeaway
This study found that a specific gene variation can lower the risk of getting type 2 diabetes in some people.
Methodology
Three common SNPs of the SLC2A9 were genotyped in 1003 Han Chinese randomly selected from Kaohsiung, Taiwan.
Potential Biases
Confounding effects of antidiabetic agents and inconsistent treatment responses could affect results.
Limitations
The study lacked accurate diagnosis of type 2 diabetes and only random glucose levels were tested.
Participant Demographics
Participants were Han Chinese, with a mix of males and females, aged around 62.5 years for the diabetes group.
Statistical Information
P-Value
0.002
Confidence Interval
95% CI = 0.03–0.45
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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