Genetic Traits of Kidney-Yang Deficiency Syndrome
Author Information
Author(s): Li Ping Zhou, Wei Jun Ding, Tan Ling Ling, Wang Mi Qu, Zhang Tian E., Li Wei Hong, Li Wan Zhen, Qin Yu Hua, Yang Hong Ya, Duan Azure, Wang Mi Qu, Ding Wei Jun
Primary Institution: Chengdu University of Traditional Chinese Medicine
Hypothesis
Do genetic alterations contribute to the development of Kidney-Yang Deficiency Syndrome (KDS)?
Conclusion
A genomic variation of the DCDC5 gene was identified, which may be related to key symptoms of KDS.
Supporting Evidence
- Five LD SNPs were identified with midrange linkage to KDS.
- Resequencing revealed a nonsynonymous variation in the DCDC5 gene.
- The S1172P substitution in DCDC5 was evaluated as possibly damaging.
- DCDC5 is involved in saccharide binding and energy metabolism.
- Two genes with established functions were identified near the LD SNPs.
Takeaway
Scientists looked at the genes of people with a condition called Kidney-Yang Deficiency Syndrome and found a change in a gene that might be important for understanding the disease.
Methodology
Genomic DNA samples from KDS subjects were genotyped using SNP arrays, and the DCDC5 gene was resequenced.
Limitations
Only exons of DCDC5 were examined, and the study involved a small sample size from a single family.
Participant Demographics
Twelve KDS subjects and three healthy spouses from a typical KDS family.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website