Frequent allelic losses at 11q24.1–q25 in young women with breast cancer: association with poor survival
1999
Genetic Changes in Young Women with Breast Cancer
Sample size: 102
publication
Evidence: moderate
Author Information
Author(s): Gentile M, Olsen K, Dufmats M, Wingren S
Primary Institution: University Hospital, Linköping, Sweden
Hypothesis
Are there molecular differences in breast cancer between younger and older women?
Conclusion
The study found a significant link between genetic alterations and poor survival in young women with breast cancer.
Supporting Evidence
- 88% of the cases exhibited loss of heterozygosity for at least one marker.
- 63% of cases showed LOH at the D17S855 marker in the BRCA1 gene.
- 43% of cases exhibited LOH at the HP53 marker in the TP53 gene.
- LOH frequencies peaked at D11S969 and D11S387 markers on chromosome 11.
Takeaway
Young women with breast cancer often have different genetic changes that can make their cancer worse.
Methodology
The study examined loss of heterozygosity at nine loci in breast cancer cases diagnosed under age 37.
Participant Demographics
Women diagnosed with breast cancer under the age of 37.
Statistical Information
P-Value
0.028
Statistical Significance
p=0.028
Digital Object Identifier (DOI)
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