A critical role for endocytosis in Wnt signaling
2006
Endocytosis is important for Wnt signaling
publication
Evidence: high
Author Information
Author(s): Jeremy T Blitzer, Roel Nusse
Primary Institution: Stanford University School of Medicine
Hypothesis
Does endocytosis play a critical role in Wnt signaling?
Conclusion
Endocytosis is essential for Wnt signaling, as it occurs in a compartment distinct from the plasma membrane.
Supporting Evidence
- Wnt proteins are rapidly taken into cells through endocytosis.
- Blocking endocytosis prevents Wnt signaling from occurring.
- Internalized Wnts may signal from a specific compartment within the cell.
Takeaway
The study shows that cells need to take in Wnt proteins through a process called endocytosis for the signaling to work properly.
Methodology
The study used L cells to examine the role of endocytosis in Wnt signaling through various inhibitors and transfections.
Digital Object Identifier (DOI)
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