Vancomycin Wound Penetration in Heart Surgery Patients
Author Information
Author(s): M. Kolek, Jana Ďuricová, Hana Brozmanová, Pavel Šištík, Jan Juřica, Klára Kaňková, Oldřich Motyka, Ivana Kacířová
Primary Institution: University Hospital Ostrava, Czech Republic
Hypothesis
Systemically administered antibiotics penetrate wound sites more effectively during negative pressure wound therapy.
Conclusion
Vancomycin effectively penetrates wound exudate in patients receiving NPWT for deep sternal wound infection after open-heart surgery.
Supporting Evidence
- The ratio of average vancomycin concentration in wound exudate to serum was higher for free concentration than for total concentration.
- Good vancomycin wound penetration was maintained on the following three days.
- The total hospital stay was significantly longer in patients with DSWI compared to those without.
Takeaway
This study shows that a medicine called vancomycin can get into wounds better when a special treatment is used after heart surgery.
Methodology
This was a prospective observational study where serum and exudate samples were collected from patients treated with NPWT for DSWI after open-heart surgery.
Potential Biases
High variability of exudate flow among NPWT patients may introduce bias.
Limitations
The study was a single-centre observational study with a small sample size, and there was no control group for comparison.
Participant Demographics
The mean age of participants was 66 years, with a male-to-female ratio of 7:3.
Statistical Information
P-Value
0.049
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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