Urinary Tartaric Acid as a Biomarker of Wine Consumption and Cardiovascular Risk
Author Information
Author(s): Inés Domínguez-López, Rosa M. Lamuela-Raventós, Cristina Razquin, Camila Arancibia-Riveros, Polina Galkina, Jordi Salas-Salvadó, Ángel M. Alonso-Gómez, Montserrat Fitó, Miquel Fiol, José Lapetra, Enrique Gómez-Gracia, José V. Sorlí, Miguel Ruiz-Canela, Olga Castañer, Liming Liang, Lluis Serra-Majem, Frank B. Hu, Emilio Ros, Miguel Ángel Martínez-González, Ramon Estruch
Primary Institution: CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III
Hypothesis
Is there an association between urinary tartaric acid, an objective biomarker of wine consumption, and the rate of cardiovascular disease events?
Conclusion
Light-to-moderate wine consumption, measured through an objective biomarker, was associated with a lower cardiovascular disease rate in a Mediterranean population at high cardiovascular risk.
Supporting Evidence
- Tartaric acid was correlated with self-reported wine consumption at baseline.
- Concentrations of 3–12 and 12–35 μg/mL were associated with lower CVD risk.
- Participants with higher urinary tartaric acid reported higher wine consumption.
- Light-to-moderate wine consumption was associated with lower CVD rates.
- Urinary tartaric acid predicted wine consumption with an area under the curve of 0.70.
Takeaway
Drinking a little bit of wine might help keep your heart healthy, and scientists found a way to measure how much wine people really drink using a special test.
Methodology
A case-cohort nested study within the PREDIMED trial with 1232 participants, using liquid chromatography-tandem mass spectrometry to measure urinary tartaric acid.
Potential Biases
Self-reported wine consumption may lead to measurement errors.
Limitations
Results may not be generalizable to other populations as participants were older individuals at high risk of cardiovascular disease living in a Mediterranean country.
Participant Demographics
Mean age of participants was 68 years, with 657 women and 575 men.
Statistical Information
P-Value
0.035
Confidence Interval
95% CI 0.27; 0.95
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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