Effect of Ro 03-8799 on Chemotherapy for Tumors in Mice
Author Information
Author(s): P.W. Sheldon, P. Gibson
Primary Institution: Institute of Cancer Research
Hypothesis
Can the nitroimidazole Ro 03-8799 enhance the effectiveness of various chemotherapeutic agents against murine tumors?
Conclusion
Ro 03-8799 significantly enhanced the effectiveness of certain chemotherapeutic agents against tumors in mice, particularly alkylating agents.
Supporting Evidence
- Ro 03-8799 enhanced the activity of melphalan by a factor of 2.2.
- The potentiation of chemotherapeutic agents was influenced by the timing of Ro 03-8799 administration.
- Ro 03-8799 did not enhance the effectiveness of non-alkylating agents like cisplatin and adriamycin.
Takeaway
Ro 03-8799 helps some cancer medicines work better in mice, especially those that damage DNA.
Methodology
Mice with implanted tumors were treated with Ro 03-8799 and various chemotherapeutic agents, and their tumor responses were measured using soft agar cloning.
Limitations
The study primarily used subcutaneous tumors, which may not fully represent the effects in other tumor types.
Participant Demographics
8-10 week old male inbred WHT/Cbi mice
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