Identifying Global Priority Pathogens for Vaccine Research
Author Information
Author(s): Hasso-Agopsowicz Mateusz, Hwang Angela, Hollm-Delgado Maria-Graciela, Umbelino-Walker Isis, Karron Ruth A., Rao Raman, Asante Kwaku Poku, Sheel Meru, Sparrow Erin, Giersing Birgitte
Primary Institution: World Health Organization
Hypothesis
Global priorities for new vaccine R&D have not been systematically identified for endemic pathogens.
Conclusion
The study identified 17 priority pathogens for new vaccine R&D that will help stakeholders respond to regional and country needs.
Supporting Evidence
- Five pathogens were common priorities across all regions: M tuberculosis, HIV-1, K pneumoniae, S aureus, and Extra-intestinal pathogenic E coli.
- Thirty-four distinct use cases were identified for new products targeting these pathogens.
- Annual deaths in children under five and contribution to antimicrobial resistance were the most heavily weighted criteria in five out of six WHO regions.
Takeaway
The researchers figured out which germs are most important to make vaccines for, so we can help more people stay healthy.
Methodology
Multi-criteria decision analysis (MCDA) surveys were conducted with stakeholders to prioritize endemic pathogens for vaccine R&D.
Potential Biases
Potential bias due to the representativeness of survey participants was not thoroughly assessed.
Limitations
The study's findings are based on data that may not fully reflect the impact of COVID-19 or other changing circumstances.
Participant Demographics
Participants worked in 89 countries, with expertise primarily in disease epidemiology and vaccine R&D.
Digital Object Identifier (DOI)
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