Maternal Antibody Transfer in Preterm and Full-term Infants
Author Information
Author(s): Kalee E. Rumfelt, Mindy Pike, Jennifer E. Stolarczuk, Ava Lekander, Adam S. Lauring, Linda O. Eckert, Janet A. Englund, Emily T. Martin, Alisa B. Kachikis
Primary Institution: University of Washington
Hypothesis
How does maternal influenza and RSV vaccination affect antibody transfer to preterm and full-term infants?
Conclusion
Maternal vaccination enhances antibody transfer to infants, particularly benefiting preterm infants.
Supporting Evidence
- Approximately 70% of pregnant persons received the influenza vaccine.
- Preterm infants had significantly lower cord to maternal IgG transfer ratios for IAV-H3 and RSV compared to full-term infants.
- Maternal and cord antibody concentrations were highest in the influenza-vaccinated group.
Takeaway
Moms who get vaccinated can pass important antibodies to their babies, helping keep them safe from viruses.
Methodology
Delivery samples from 115 maternal-infant pairs were analyzed for RSV and influenza antibodies using electrochemiluminescence assays.
Potential Biases
Potential bias due to reliance on self-reported vaccination status.
Limitations
Unable to document prior infections and did not follow participants for infections after birth.
Participant Demographics
Participants included pregnant individuals with singleton pregnancies, with a majority being vaccinated against influenza.
Statistical Information
P-Value
p ≤ 0.05
Statistical Significance
p ≤ 0.05
Digital Object Identifier (DOI)
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