Association of NOS3 Gene Polymorphisms with Hypoxic-Ischemic Encephalopathy
Author Information
Author(s): Šamija Radenka Kuzmanić, Primorac Dragan, Rešić Biserka, Lozić Bernarda, Krželj Vjekoslav, Tomasović Maja, Stoini Eugenio, Šamanović Ljubo, Benzon Benjamin, Pehlić Marina, Boraska Vesna, Zemunik Tatijana
Primary Institution: Department of Medical Biology, University of Split, School of Medicine, Split, Croatia
Hypothesis
To test the association of NOS3 gene with hypoxic-ischemic encephalopathy (HIE).
Conclusion
Despite the limited number of HIE patients, we observed genotypic and haplotype associations of NOS3 polymorphisms with HIE.
Supporting Evidence
- SNP rs1808593 showed genotype association with HIE (P=0.008).
- rs1800783-rs1800779 TG haplotype showed an association with HIE (P<0.001).
- The study had 80% statistical power to detect an effect with odds ratios for various SNPs.
Takeaway
The study looked at how certain genes might affect brain injury in babies. They found some links between gene variations and the risk of brain problems.
Methodology
The study included 110 children with HIE and 128 controls, analyzing 7 SNPs in the NOS3 gene using real-time PCR.
Limitations
The study had a small sample size and potential population stratification.
Participant Demographics
110 children with HIE (69 boys, 41 girls) and 128 controls (60 boys, 68 girls).
Statistical Information
P-Value
0.008
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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