Impact of Hydrogenated Fat Diet on Offspring Health
Author Information
Author(s): Pisani Luciana P, Oller do Nascimento Claudia M, Bueno Allain A, Biz Carolina, Albuquerque Kelse T, Ribeiro Eliane B, Oyama Lila M
Primary Institution: São Paulo Federal University – UNIFESP
Hypothesis
Does feeding pregnant and lactating rats hydrogenated fats rich in trans fatty acids affect the health of their offspring?
Conclusion
Maternal intake of hydrogenated vegetable fat during pregnancy and lactation leads to increased PAI-1 gene expression and insulin levels in adult offspring.
Supporting Evidence
- Offspring of mothers fed hydrogenated fats had increased PAI-1 gene expression.
- Insulin receptor levels were higher in offspring exposed to hydrogenated fats.
- Body weight gain was lower in offspring of mothers fed hydrogenated fats.
Takeaway
Feeding mother rats unhealthy fats during pregnancy can make their babies more likely to have health problems when they grow up.
Methodology
Pregnant and lactating Wistar rats were fed either a control diet or a diet enriched with hydrogenated vegetable fat, and their offspring were analyzed at 90 days old.
Potential Biases
Potential bias in dietary control and environmental conditions during the study.
Limitations
The study was conducted on rats, which may not fully represent human outcomes.
Participant Demographics
Wistar rats, specifically pregnant and lactating females and their male offspring.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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