SNIP/p140Cap as a Prognostic Factor in Breast Cancer
Author Information
Author(s): Kennedy S, Clynes M, Doolan P, Mehta J P, Rani S, Crown J, O'Driscoll L
Primary Institution: St Vincent's University Hospital, Dublin; National Institute for Cellular Biotechnology, Dublin City University
Hypothesis
Is SNIP/p140Cap mRNA expression a useful diagnostic and prognostic marker for breast cancer?
Conclusion
SNIP/p140Cap mRNA expression is significantly associated with poorer overall survival in breast cancer patients.
Supporting Evidence
- SNIP/p140Cap mRNA was detected in approximately 37% of breast tumors.
- Expression of SNIP/p140Cap was significantly associated with larger tumor size.
- Patients with SNIP/p140Cap expression had shorter overall survival times.
Takeaway
This study found that a specific marker called SNIP/p140Cap is present in some breast cancer tumors and is linked to worse survival outcomes.
Methodology
The study analyzed SNIP/p140Cap mRNA expression in 103 breast tumor biopsies using quantitative reverse-transcriptase PCR.
Potential Biases
Potential biases in patient selection and retrospective data collection.
Limitations
The study is retrospective and may not account for all confounding factors.
Participant Demographics
Patients aged 31 to 90 years, with a mean age of 58 years; included both pre- and post-menopausal women.
Statistical Information
P-Value
0.037
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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