Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor
1999
Microsatellite Instability in Colorectal Cancer
Sample size: 181
publication
Evidence: moderate
Author Information
Author(s): Salahshor S, Kressner U, Fischer H, Lindmark G, Glimelius B, Påhlman L, Lindblom A
Primary Institution: Karolinska Institute
Hypothesis
Does the presence of microsatellite instability (MSI) in colorectal tumors provide prognostic information?
Conclusion
The presence of microsatellite instability does not independently predict prognosis in colorectal cancer.
Supporting Evidence
- 12% of the tumors showed microsatellite instability.
- Survival analysis showed no significant difference in prognosis between MSI-positive and -negative tumors.
Takeaway
This study found that having a certain type of genetic change in colorectal cancer doesn't help doctors predict how well a patient will do.
Methodology
Survival analysis was conducted on 181 unselected colorectal tumors to assess the prognostic value of MSI.
Limitations
The study only included unselected colorectal tumors, which may not represent all cases.
Digital Object Identifier (DOI)
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