Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation
2008
Cyclin D1 and Cancer: Understanding Its Role in Tumor Growth
publication
Evidence: moderate
Author Information
Author(s): Laura L Pontano, J Alan Diehl
Primary Institution: The Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA, USA
Hypothesis
Is cyclin D1 overexpression a significant contributor to tumorigenesis or merely a consequence of neoplastic transformation?
Conclusion
Nuclear accumulation of cyclin D1-dependent kinase during S-phase is critical for transformation and contributes to genomic instability.
Supporting Evidence
- Cyclin D1 overexpression is common in many cancers but does not alone drive transformation.
- Mutations in cyclin D1 that prevent its degradation lead to its accumulation and promote cancer.
- Nuclear cyclin D1/CDK4 complexes can cause genomic instability by interfering with DNA replication processes.
Takeaway
Cyclin D1 helps cells grow, but if it doesn't get removed properly, it can cause problems like cancer.
Digital Object Identifier (DOI)
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