Impact of Lymphovascular Invasion in Node-Negative Gastric Cancer
Author Information
Author(s): Alangari Abdullah Ibrahim, Kim Sojung, Lee Han Hong, Song Kyo Young, Seo Hoseok
Primary Institution: Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea
Hypothesis
What is the clinical significance of lymphovascular invasion (LVI) in patients with node-negative gastric cancer?
Conclusion
Lymphovascular invasion is a significant prognostic indicator in node-negative gastric cancer, associated with increased risk of disease recurrence and poor survival, particularly in the T2 cohort.
Supporting Evidence
- LVI positivity was an independent risk factor for overall survival in T2N0 patients.
- The T2N0 LVI-positive group exhibited significantly poorer prognosis than the T2N0 LVI-negative group.
- Patients with LVI-positive gastric cancer had a higher tendency for recurrence in distant lymph nodes and distant organs.
Takeaway
If cancer spreads to the lymph vessels, it can make the disease worse, even if the lymph nodes look fine. This study shows that doctors should pay attention to this when treating gastric cancer.
Methodology
A retrospective review of 5,699 patients who underwent curative radical gastrectomy for gastric cancer was conducted, comparing survival based on LVI status.
Potential Biases
Potential selection bias due to the retrospective nature of the study.
Limitations
As a single-center retrospective study, there may be selection bias, and future prospective research is needed.
Participant Demographics
Patients included were diagnosed with gastric adenocarcinoma and underwent curative radical gastrectomy between 1989 and 2018.
Statistical Information
P-Value
0.001
Confidence Interval
1.398 to 3.280
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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