6-(4-Bromophenyl)-2-(4-fluorobenzyl)imidazo[2,1-b][1,3,4]thiadiazole
2011
Study of a New Imidazothiadiazole Compound
publication
Evidence: moderate
Author Information
Author(s): Banu Afshan, Begum Noor Shahina, Lamani Ravi S., Khazi I. M.
Primary Institution: Bangalore University
Hypothesis
The presence of a fluoro substituent in imidazothiadiazole derivatives enhances their biological activity.
Conclusion
The crystal structure of the new compound shows that the imidazothiadiazole and bromophenyl rings are nearly planar and stabilized by intermolecular interactions.
Supporting Evidence
- The imidazothiadiazole and bromophenyl rings are nearly planar with small deviations.
- The dihedral angle between the fluorobenzyl and imidazothiadiazole rings is almost orthogonal.
- The molecular structure is stabilized by strong and weak intermolecular interactions.
Takeaway
Scientists created a new chemical compound and found that its structure is stable and has interesting properties.
Methodology
The compound was synthesized by refluxing equimolar quantities of 2-amino-(4-fluorobenyl)-1,3,4-thiadiazole and phenacyl bromide in dry ethanol.
Digital Object Identifier (DOI)
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