Tocotrienol Supplementation Improves Health in Older Adults
Author Information
Author(s): Chin Siok-Fong, Ibahim Johari, Makpol Suzana, Abdul Hamid Noor Aini, Abdul Latiff Azian, Zakaria Zaiton, Mazlan Musalmah, Mohd Yusof Yasmin Anum, Abdul Karim Aminuddin, Wan Ngah Wan Zurinah
Primary Institution: Universiti Kebangsaan Malaysia
Hypothesis
Does Tocotrienol Rich Fraction (TRF) supplementation improve lipid profile and oxidative status in healthy older individuals?
Conclusion
Tocotrienol supplementation improved plasma cholesterol and antioxidant levels, particularly in individuals over 50 years of age.
Supporting Evidence
- HDL-cholesterol levels increased significantly in the TRF group after 6 months.
- Protein carbonyl levels decreased significantly in the TRF group after 6 months.
- Total vitamin E levels increased significantly in the TRF group after 3 months.
- Antioxidant enzyme activities showed significant changes in the older group.
Takeaway
Taking a special vitamin E called tocotrienol can help older people have better cholesterol and less damage from things that can hurt their cells.
Methodology
62 healthy older adults were randomly assigned to receive either TRF or placebo for 6 months, with blood samples taken at baseline, 3 months, and 6 months.
Potential Biases
Potential bias in participant selection and self-reported compliance.
Limitations
The study was limited to healthy older adults and may not apply to other populations.
Participant Demographics
Participants were aged 35 years and older, with equal representation from two age groups: 35-49 years and over 50 years.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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