Ovarian Cancer Risk and Genetic Variation in SHBG
Author Information
Author(s): Montserrat Garcia-Closas, Louise A Brinton, Jolanta Lissowska, Douglas Richesson, Mark E Sherman, Neonila Szeszenia-Dabrowska, Beata Peplonska, Robert Welch, Meredith Yeager, Witold Zatonski, Stephen J Chanock
Primary Institution: National Cancer Institute, National Institutes of Health
Hypothesis
Is common genetic variation in the SHBG gene associated with the risk of epithelial ovarian cancer?
Conclusion
The study found no substantial association between common genetic variation in SHBG and ovarian cancer risk.
Supporting Evidence
- The study included 264 women with ovarian cancer and 625 controls.
- No SNPs evaluated were significantly associated with ovarian cancer risk.
- The study had a high participation rate among eligible subjects.
Takeaway
The study looked at whether certain genes might affect the risk of getting ovarian cancer, but it didn't find any strong links.
Methodology
A population-based case-control study involving 264 women with ovarian cancer and 625 controls, analyzing genetic variations.
Potential Biases
Selection bias may have been introduced due to the collection of DNA samples.
Limitations
The study had limited power to detect weak associations and potential selection bias due to DNA sample collection.
Participant Demographics
Participants were Polish women aged 20-74, primarily of Caucasian origin.
Statistical Information
P-Value
0.06
Confidence Interval
0.22–1.02
Digital Object Identifier (DOI)
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